The long-awaited Federal Reserve Open Market Committee (FOMC) meeting is widely expected to result in an interest rate hike, which would be the second rate rise in a decade.
On the data front, the Producer Price Index rose 0.4 percent in November, above the expected 0.1 percent increase. Meanwhile, November retail sales rose less than expected as households cut back on purchases of motor vehicles. Industrial production, capacity utilization and business inventories are all set to be released later on Wednesday morning.
In Europe, the pan-European Stoxx 600 index was around 0.31 percent lower on Wednesday. In Asia, the Shanghai Composite in China closed 0.45 percent lower, while the Nikkei in Japan closed 0.02 percent higher.
A reported rise in U.S. crude inventories and an estimate that OPEC may have produced more crude in November than previously predicted appears to have undermined a planned cut to production, according to a Reuters report.