Eisman, whose bet against the subprime housing market prior to the 2008 financial crisis was depicted in "The Big Short," told CNBC Monday he believes Trump will roll back on financial regulations, and would be as "long as I can be" on financial stocks.
Cramer said he doesn't know how Eisman can "understand or can rationalize" his assessment.
"Look, it is very easy to say, 'I think the market is going up big and I don't think any of this stuff Trump's going to do is going to happen.' And you can say, 'How are you going to say that? Cause I just said it," Cramer said on "Squawk Box."
He continued: "He contradicted a previous guest, said the guest didn't know what he was talking about. Look, you can say what you want. There's fake news, real news, there's Reddit, there's sites. Say whatever you want. I don't know. I'm stuck with the facts."
— CNBC's Matthew J. Belvedere contributed to this report.