U.S. stock index futures pointed to a lower open on Wednesday, with the Nasdaq composite set to fall from a record high after mixed quarterly results from Apple.
The tech giant posted better-than-expected adjusted earnings per share, but iPhone sales missed analyst expectations. Shares of Apple fell more than 1 percent in the premarket.
The tech-heavy Nasdaq posted record highs on an intraday and closing basis on Tuesday before Apple released its quarterly results.
Investors also awaited the Federal Reserve's latest policy decision on interest rates.
It's the second day of the Fed's policy meeting. A decision from the central bank is due in the afternoon around 2 p.m. ET, but markets expect the Fed to hold steady. It has forecast two more interest rates hikes for this year, and the market thinks odds are greater than 50 percent that the next hike will come in June.
On the data front, the U.S. private sector created 177,000 jobs last month, according to a report from ADP and Moody's Analytics. Economists polled by Reuters expected an addition of 175,000 jobs.
The ADP and Moody's Analytics report is seen as a preview to the government's monthly jobs report, which will be released Friday.
We'll also get the final Markit services PMI reading for April, as well as the ISM non-manufacturing reading.
On the earnings front, AIG, Facebook, Kraft-Heinz and Tesla are due to report after the bell.
In Europe, the pan-European Stoxx 600 index was around 0.2 percent lower on Wednesday morning. In Asia, the Shanghai Composite in China closed 0.25 percent lower, while the Nikkei in Japan closed 0.7 percent higher.
In oil markets, Brent crude traded at around $50.75 a barrel on Friday, up 0.57 percent, while U.S. crude was around $47.86 a barrel, up 0.48 percent.
CNBC's Patti Domm contributed to this report