In an interview on "Squawk on the Street," Whitman said the company is "almost all the way through probably one of the largest transformations in American business history."
"By the time we're done, we will have created four industry-leading companies that I think are much better equipped to win in their markets," Whitman said.
"Margins were under pressure this quarter but largely from one-time events," she said. "You recall we sold 51 percent of our China business. … We made six acquisitions in the last six months, and there is some dilution associated with this acquisitions."
The comment came after HPE sold its consulting and outsourcing services unit and signed a deal to sell its software division.
Shares of Palo Alto, California-based HPE were lower on Thursday, a day after the tech company reported a steep fall in revenue in its servers business in its second-quarter earnings.