But there is a bigger question that "Spider-Man: Homecoming" may answer: Will fans burn out as studios introduce new spins on popular superheroes, or can they continue to reinvent these characters and keep cashing in?
"Franchise fatigue is always a concern for any series as well-represented on the big screen as this character has been over the past 15 years, but the pros definitely seem to outweigh the cons in this case," said Shawn Robbins, chief analyst at BoxOffice.com.
BoxOffice.com is betting "Spider-Man: Homecoming" will outperform expectations and drum up $125 million in its U.S. opening, as strong reviews following early screenings boost the buzz ahead of next week's debut.
"Spider-Man: Homecoming" currently has a 92 percent "Fresh" rating on RottenTomatoes, and it's the most talked about movie on social media right now, according to comScore.
More importantly, that conversation is mostly positive.
Nearly 60 percent of tweets hashtagged #SpidermanHomecoming were positive between June 24-29, according to marketing technology firm Amobee. Audience data firm Taykey's reading of social media produced a similar rating.
About 6,000 tweets mentioned both Tom Holland and Spider-Man during the same period, with 47 percent positive and just 2 percent negative, according to Amobee. Roughly a quarter of digital content engagement around Spider-Man's alter-ego Peter Parker has been related to Holland over the last year.
Comic book movie social media sentiment, source: Taykey
Reinvention and reinterpretation are part of the superhero genre because different writers and artists regularly take over the characters, said Jonathan Cohen, principal brand analyst at Amobee.
"On the big screen, these characters have proven to be equally as pliable to new interpretations," he told CNBC in an email. "Recasting or rebooting a franchise isn't nearly as risky as it might initially seem."
There's also a concern that older audiences won't buy into Holland's Spider-Man, who skews younger than past incarnations. Yet much of the social media conversation around "Spider-Man: Homecoming" is happening among millennial men, according to analysis by Taykey.
That may indicate that older audiences are not turned off by the prospect of a sophomoric Spider-Man.
Sony and Marvel appear to have hedged their bets to some degree. By having fan-favorite Robert Downey Jr. appear as Iron Man, it serves to bridge the generation gap, said comScore's Dergarabedian. Still, he also believes Holland's fresh-faced Spidey offers fans something new.
"Spider-Man certainly is one of those crown jewels of the superhero world, and that's why they keep rebooting it and going back to it and trying to reinvent it and re-imagine it for today's audiences," Dergarabedian said.