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Cliff Asness believes financial markets will offer weak returns from these levels.
"More expensive markets lead to lower expected returns," Asness said at the 2nd Annual Evidence-Based Investing Conference in New York on Thursday. He added that "both stocks and bonds [will offer] lower expected returns than normal."
Asness predicts investors with a balanced portfolio of stocks and bonds will only generate 2 percent real annual returns.
The portfolio manager warned however not to bet against or short the market.
"Don't market time with this. Valuation of markets is a disastrous market timing tool and a super weak strategy," he said. "Evidence is strong over long-term, high CAPE [multiples mean returns for the] next 10 years are low."
Nobel Prize-winning economist Robert Shiller developed the "cyclically adjusted price-to-earnings ratio" (CAPE) market valuation measure, which is calculated using price divided by the index's average historical 10-year earnings, adjusted for inflation.
Asness is founder and chief investment officer of AQR Capital Management, a leading quantitative investing firm. AQR has $208 billion of assets under management, according to its website.