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The cryptocurrency, which has surged more than 1,000 percent this year, broke above the $12,000 mark on Wednesday morning, according to industry site CoinDesk. Bitcoin's rapid gains have prompted some market participants to warn of a bubble.
"It's kind of like 'Monopoly' money," Cramer said on "Squawk Box. " "Obviously, there's people who use it. If you ever say anything bad about it, there's like this 'bitcoin mafia' that comes after you. But it is an oddity that has nothing to do with us" as investors.
"It's just pure gambling at this point," Cramer continued. "I mean if you want to gamble, go to Vegas. Vegas is fabulous."
"I mean honestly, what's the difference between bitcoin and trying to figure out the Super Bowl? I mean it's gambling," the host of CNBC's "Mad Money" added.
Late last month, Cramer said the cryptocurrency's velocity is a sign that its surge is "parabolic," and that could mean the rally won't last.
Cramer's comments resembled those of closely followed trader Art Cashin.
In a CNBC interview Wednesday, Andrew Busch, chief market intelligence officer at the Commodity Futures Trading Commission, addressed the new bitcoin futures products coming to the market. "Our role as a derivatives regulator is to make sure the futures contract it's not manipulated. We're going to do do that for sure. "