Auto and bank stocks fell the furthest Wednesday, with both sectors down roughly 1 percent.
Tech stocks have come under pressure recently amid concern that the chip market boom could soon come to an end. But, the sector recovered roughly half of 1 percent in afternoon trade, ultimately closing 0.56 percent lower.
The food and beverages sector was 0.77 percent higher.
Looking at individual stocks, Steinhoff shares crashed on Wednesday after the retail group announced it had launched an investigation into accounting irregularities after the CEO had resigned. Its shares closed over 63 percent lower on the news.
The U.K.'s Saga was another big faller Wednesday, down more than 21 percent after a profit warning. The company, which specializes in over-50s travel and insurance, said profits in the current financial year would grow more slowly than anticipated.
Meanwhile, British shopping center investment firm Hammerson announced Wednesday it had agreed to buy Intu Properties in a deal worth approximately £3.4 billion ($4.56 billion). Shares of Intu Properties topped the Stoxx 600 Wednesday afternoon, rallying nearly 14 percent by the end of the day.
Stateside, U.S. equities rebounded following a lower open. Tech stocks bounced back from falls in recent days, as investors kept an eye on news concerning tax reform coming out of Washington.