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"There is no one fighting for free trade. There is no one fighting for opening markets but [instead] closing US markets to foreign companies and foreign competitors," he said.
He accused Airbus rival Boeing of "ruthlessly surfing" on the US protectionist wave to smother competition.
He cited the legal challenges by its competitor against Bombardier's C-series regional aircraft which have led to proposals by the US department of trade for tariffs of 300 per cent on that type of aircraft sold in the US.
"This strategy may bring short-term success but it will be self-defeating in the end," he said. "It hurts our industry."
Airbus last year struck a deal to acquire the C series from Bombardier for a nominal sum of $1 in what is widely regarded as a coup for the European aircraft maker which has long aimed to increase its presence in the US market.
Airbus plans to manufacture the aircraft at its plant in Mobile, Alabama, to avoid the tariff if it is imposed next month.
Boeing's response has been to open discussions with Brazilian aircraft maker Embraer.
Boeing said last night: "Boeing believes in strong competition, rules-based trade and a level playing-field for all in the industry. Competitors must abide by the rules that everyone has agreed will govern the competition. Those who don't abide by the rules are the ones that are 'taking advantage' and harming the wider industry."
The Airbus boss also warned against the implications of Britain's exit from the EU. "The wreckage that President Trump will leave after four or eight years in the White House will be easier to repair than the exit of the UK from the EU."
Mr Enders said that Brexit would strain the efficiency of operations, add costs and "thereby curtail the competitiveness" of the aerospace industry.
His comments will raise concerns already emerging about the Franco-German group's commitment to the UK and the pressure to take manufacturing operations back to France, Germany or Spain.
Mr Enders said he hoped that Britain would always be a home country for Airbus. The UK business remained Airbus's most efficient and innovative operation, he said.
However, whatever industry did to mitigate the effects of weakening ties between Britain and the EU, "the result of Brexit would be negative".