Elsewhere, Seoul's benchmark Kospi reversed losses to close up 0.42 percent at 2,485.52. Heavyweight tech names were mixed following the slump in tech names stateside overnight, with Samsung Electronics rising 0.91 percent. Among major sectors, automakers and manufacturing names also recorded gains.
Steelmakers traded mixed following news from Yonhap News Agency that South Korea is requesting for an exemption from recently announced U.S. steel tariffs. Posco closed lower by 0.73 percent while Hyundai Steel rose 1.18 percent.
The Hang Seng Index tacked on 0.12 percent by 3:08 p.m. HK/SIN as gains in technology and consumer goods names were partially offset by losses in financials.
On the mainland, the Shanghai composite edged up 0.34 percent to close at 3,290.46 and the Shenzhen composite added 0.23 percent to end at 1,872.33.
Meanwhile, Sydney's S&P/ASX 200 slipped by 0.39 percent to end at 5,936.40. Losses were led by the 1.35 percent fall in materials stocks. The heavily weighted financials subindex held just above the flat line, adding 0.05 percent.
"Amid ongoing concerns with regards to the U.S. administration as well as the potential for heightened global trade tensions, expect investor sentiment to remain fragile intraday and ahead of the FOMC," Emmanuel Ng, an economist at OCBC Bank, said in a note.
Stocks stateside closed lower on Monday, with losses led by the Nasdaq composite's 1.84 percent fall.
The index recorded its worst day since Feb. 8 as Facebook sank 6.8 percent on the back of a scandal involving data analytics firm Cambridge Analytica. Cambridge Analytica accessed the data of 50 million Facebook users without their permission, reports said.