The PCE price index was unchanged on a monthly basis after advancing 0.2 percent in February.
Excluding the volatile food and energy components, the PCE price index soared 1.9 percent in the 12 months through March, the biggest increase since February 2017, after increasing 1.6 percent in February. The so-called core PCE price index rose 0.2 month-on-month in March after a similar gain in February.
The core PCE index is the Fed's preferred inflation measure. Last month's increase was in line with economists' expectations.
Minutes of the Fed's March 20-21 policy meeting published this month showed officials expected the annual PCE price indexes to accelerate in March partly because of "the arithmetic effect of the soft readings on inflation in early 2017 dropping out of the calculation."
The minutes also noted that the rise in inflation emanating from the so-called base effects "by itself, would not justify a change in the projected path" for the central bank's benchmark overnight interest rate.
Fed officials are scheduled to convene on Tuesday and Wednesday for a regular policy meeting. The Fed raised rates last month and forecast at least two more rate hikes for this year.
Away from the favorable base effects, inflation is rising thanks to a tightening labor market. The government reported last Friday that wages and salaries recorded their biggest increase in 11 years in the first quarter. Faster economic growth, driven by a $1.5 trillion tax cut package and increased government spending, is also seen stoking inflation.
The Commerce Department's report on Monday also showed consumer spending increased 0.4 percent in March after being unchanged in February. The data was included in last Friday's advance first-quarter gross domestic product report.
Consumer spending, which accounts for more than two-thirds of U.S. economic activity, grew at a 1.1 percent annualized rate in the January-March period, the slowest in nearly five years, after surging at a 4.0 percent pace in the fourth quarter.
As result of the weakness in consumer spending, the economy grew at a 2.3 percent rate in the first quarter after expanding at a 2.9 percent pace in the final three months of 2017.
When adjusted for inflation, consumer spending increased 0.4 percent in March. The so-called real consumer spending fell 0.2 percent in February. Personal income rose 0.3 percent in March after increasing by the same margin in February.
Wages gained 0.2 percent in March after rising 0.4 percent in the prior month. Savings fell to $460.6 billion in March from $483.1 billion in February. The saving rate slipped to 3.1 percent from 3.3 percent in February.