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McConnell, a Republican, filed a petition for a so-called cloture vote, which if successful would limit debate on the Kavanaugh nomination and start the clock ticking on a final 30-hour waiting period before the Senate could vote to confirm the nominee.
After filing a cloture petition, lawmakers must wait one legislative day before proceeding to the cloture vote, according to Senate rules. That means a cloture vote could come on Friday morning at the soonest.
That news comes as the FBI's report on sexual misconduct allegations against U.S. Supreme Court nominee Brett Kavanaugh neared completion late on Wednesday as the battle over his selection by President Donald Trump approached a new turning point.
The Senate was expected to receive the report by early Thursday, two sources familiar with the matter said. Senators were to be granted access to review it during the day on Thursday.
While the report's conclusions were as yet unknown, there was already a partisan battle over it as Trump and the Senate Republican leadership battled to corral enough support for a majority vote for Kavanaugh in the days ahead.
Democrats were in near unanimity against Kavanaugh, a conservative federal appeals court judge.
"It's time to put this sickening display behind us," McConnell said in remarks on the Senate floor earlier in the day. "The Senate will vote on this nomination this week."
Several people with information related to allegations against Kavanaugh told Reuters they had not heard from the FBI, suggesting its report may be narrower than was desired by some of the lawmakers who demanded it just days ago.
Christine Blasey Ford, a college professor from California who accused Kavanaugh of assaulting her in 1982 when they were high school students, has not been contacted by the FBI, her attorneys said.
As Senate Republican leaders marched toward a final vote on Kavanaugh's nomination, perhaps over the weekend, the three Republicans who could be key to whether Kavanaugh is confirmed — Senators Jeff Flake, Susan Collins and Lisa Murkowski — criticized Trump for his remarks about Ford at a political rally in Mississippi on Tuesday.
Ford, who testified last week at an extraordinary Senate Judiciary Committee hearing, said she could not remember the precise date or location of the alleged assault or how she got home later, but offered a detailed account of the incident.
She said a drunken Kavanaugh pinned her down, tried to remove her clothing and covered her mouth when she screamed.
Imitating Ford's testimony, Trump, who was himself accused during the 2016 presidential race of sexual misconduct with numerous women, said: "What neighborhood was it in? I don't know. Where's the house? I don't know. Upstairs, downstairs, where was it? I don't know. But I had one beer. That's the only thing I remember."
"And a man's life is in tatters," Trump added.
Flake told NBC's "Today" show that "there's no time and no place for remarks like that, that discuss something this sensitive at a political rally ... It's kind of appalling."
Collins told reporters: "The president's comments were just plain wrong."
She did not respond when asked if his comments would affect her vote on Kavanaugh's confirmation.
Asked whether Trump's comments would affect her vote, Murkowski told reporters: "I am taking everything into account. The president's comments yesterday mocking Dr. Ford were wholly inappropriate and, in my view, unacceptable."
A day after the hearing, Trump had called Ford "a very credible witness" who provided "very compelling" testimony.
Kavanaugh has denied Ford's accusation as well as allegations by two other women, all dating from the 1980s, while accusing Democrats of a political "hit."