Retailers could be in for a jolly jump in holiday sales despite headwinds like the U.S.-China trade war and threat of another economic slowdown.Retailread more
Damage to the top OPEC producer's oil facilities ignited fears of supply disruption around the world and has sent crude prices soaring.Energyread more
After a series of setbacks on the road to an initial public offering, the parent company of real estate start-up WeWork is delaying the move, sources told CNBC Monday.Technologyread more
Apple isn't trying to blow our minds with groundbreaking new features on the iPhone 11, but is making lots of little improvements each year, this year focusing on cameras and...Technologyread more
Saudi Arabia's defense spending is the world's third-largest — behind the U.S. and China, says Gary Grappo, former U.S. ambassador to Oman.Energyread more
Chinese officials are expected to be in Washington this week to hold consultations with the U.S. ahead of high-level trade talks in October.World Economyread more
The ballot comes at a precarious time for the country's longest serving prime minister, with the right-wing incumbent facing formidable challenges.World Politicsread more
Iran will never hold talks with America, the country's Supreme Leader Ayatollah Ali Khamenei said on state television Tuesday morning.Politicsread more
Energy stocks are on fire Monday. Five experts weigh in on what this could mean.Trading Nationread more
President Donald Trump said Monday he's in no rush to respond to a coordinated attack that hit Saudi Arabia's oil industry over the weekend.Marketsread more
The price of oil could go sharply higher, depending on the duration of the disruption at Saudi oil facilities and whether there is a military response.Powering the Futureread more
Roche is buying U.S.-based gene therapy specialist Spark Therapeutics for $4.3 billion after developments in this area convinced the Swiss drugmaker to "step up", Chief Executive Severin Schwan said on Monday.
Roche will pay $114.50 per share for Spark, more than twice the U.S. company's closing price on Feb. 22, for a portfolio that includes a blindness treatment that has U.S. and European approval and other projects for haemophilia and neurodegenerative disorders like Huntington's disease.
Basel-based Roche is buying Spark as rivals, including Novartis, also move aggressively into gene therapy, where treatments for rare, inherited diseases command some of the highest prices in medicine. Spark's blindness therapy Luxturna is priced at $850,000 per patient.
"We've been watching this space for quite some time. We just feel it's now the right time to step up," Schwan told Reuters in an interview.
"The fit of Spark and Roche is really excellent. It provides us with a broad portfolio, it provides us with expertise across the value chain."
Schwan is counting on new medicines, including gene therapies, to help compensate for patent losses on his $21-billion-per-year trio of cancer medicines Rituxan, Herceptin and Avastin, that are facing competition from cheaper copies.
Roche, the biggest cancer drugs maker, was late to the game in immuno-oncology where Merck's Keytruda is becoming the dominant player and has eclipsed Roche's own product, Tecentriq, that seeks to harness the body's immune system to fight cancer.
Bank Vontobel analysts said the Spark deal gives Roche a proven platform for commercialising gene therapies, but did not come without risks -- including getting beaten to market by rivals with similar treatments in the works.
Roche shares were 0.4 percent lower by 1140 GMT.
Gene therapies use specially engineered viruses, or viral vectors, to deliver genetic material into defective cells, in hopes of improving or potentially even curing an inherited condition.
Luxturna, sold in the United States by Spark and elsewhere by Novartis after its approval in 2017, targets a rare genetic disease, Leber's congenital amaurosis, that causes blindness in about 1 in 200,000 people.
Loss-making Spark had $51.6 million in revenue in the first nine months of 2018 from Luxturna and also had income from a deal with Pfizer, which it is partnering on another gene therapy for haemophilia B.
Philadelphia-based Spark's shares are up about 30 percent this year. The U.S.-company's stock tumbled last year after two of 12 patients showed an unfavourable immune response when treated with a higher dose of Spark's haemophilia therapy SPK-8011.
Schwan said Roche was satisfied that the issues that emerged could be addressed with steroid treatment.
Roche's Spark deal, seen closing in the second quarter, follows Novartis's $8.7 billion purchase of U.S.-based Avexis last year, also to gain a platform of gene therapies for disorders including spinal muscular atrophy.
Novartis has made gene therapy one of its focus areas, giving it a head start on Roche. U.S. approval of Novartis's SMA medicine is slated for coming months.
Among Spark's top drug hopefuls is SPK-8011, for haemophilia A, expected to start Phase 3 trials in 2019. It is also working on treatments for Pompe disease, blindness-causing choroideremia and Huntington's disease.
"The needs of patients and families living with genetic diseases are immediate and their needs vast," Spark Chief Executive Jeffrey Marrazzo said.
Roche already sells Hemlibra against haemophilia A that helps stop bleeding in patients with the genetic disorder that prevents their blood from clotting. Hemlibra, approved in 2017, had 224 million Swiss francs ($224.18 million) in sales last year.
Schwan said he was not worried about gene therapy and Hemlibra cannibalising sales from each other. "Our best guess is, it is complementary and that actually patients will need both options -- a medicine like Hemlibra, and increasingly over time, gene therapy," he said.
"We view Biomarin likely first to market," Vontobel analyst Stefan Schneider said. "We view the market opportunity big enough to accommodate more than one gene therapy - but a favourable safety profile will likely win gold." ($1 = 0.9992 Swiss francs)