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Intel was up more than 6% in after-hours trading. Apple stock was flat on the announcement.
2,200 Intel employees are joining Apple, according to the announcement. Apple paid $1 billion for employees, intellectual property and other equipment from Intel. The deal is expected to close in the fourth quarter of 2019.
"Today we announced the sale of the majority of our 5G smartphone modem business to Apple," Intel CEO Bob Swan said on a conference call discussing company earnings. "This deal preserves Intel access to critical IP we have developed and enables us to focus on the more profitable 5G network opportunity where we are growing and winning share."
Apple currently purchases Intel modems for iPhones, which allow it to connect to networks operated by carriers such as Verizon and AT&T. But in April, Intel announced that it planned to leave the smartphone modem market because Intel had "no clear path to profitability and positive returns," Swan said at the time.
Apple was Intel's only modem customer.
As part of the deal, Intel will be able to develop modems for devices that aren't smartphones, the companies said, including PCs, connected industrial devices and autonomous vehicles.
Goldman Sachs was Intel's advisor on the deal.
Apple will buy modem chips from Qualcomm in the near-term. Earlier this year, as part of a settlement over patent licensing, Apple agreed to buy Qualcomm chipsets for multiple years, suggesting that Qualcomm will provide modem chips for future iPhones, including future versions that may support 5G networks.
Qualcomm dropped 1% in after-hours trading.
Apple is widely believed to be building its own 5G chipset, according to media reports and job listings. The intellectual property it receives from Intel will be critical to that effort, analysts say, but it is likely to be a long-term, multi-year effort given the complexity of the technology.
"Apple does realize it's not another chip — it's strategic intellectual property in a connected device," said Prakash Sangam, founder of Tantra Analyst, a research and advisory firm, previously told CNBC. "This is one of the key strategic pieces of IP they don't have, and it makes sense to own it."
"For Cupertino this would be a clear 'doubling down' on 5G which remains at the centerpiece of the company's smartphone future with these chip assets giving Apple further control over its supply chain and core chip design," Wedbush analyst Dan Ives wrote in a note on Monday.
Apple now owns 17,000 wireless technology patents, when the recent Intel purchases are included, it said on Thursday.
"Apple is excited to have so many excellent engineers join our growing cellular technologies group," Apple Senior Vice President of Hardware Technologies Johny Srouji said in a statement. "They, together with our significant acquisition of innovative IP, will help expedite our development on future products and allow Apple to further differentiate moving forward."