Biotech and Pharma

Separate GSK, AstraZeneca trial results may widen ovarian cancer drug use

Key Points
  • GlaxoSmithKline and AstraZeneca both reported trial results that will likely make their competing drugs available to a wider group of ovarian cancer patients.
  • The results may help GSK catch its rival in a highly contested drug class.
  • The companies said their respective drug candidates staved off the return of metastasized ovarian cancer in women who had responded to initial standard treatment, reducing the risk of a relapse.

GlaxoSmithKline and AstraZeneca both reported trial results that will likely make their competing drugs available to a wider group of ovarian cancer patients, possibly helping GSK catch its rival in a highly contested drug class.

The companies said separately on Saturday their respective drug candidates — in a class known as PARP inhibitors — staved off the return of metastasized ovarian cancer in women who had responded to initial standard treatment, reducing the risk of a relapse.

AstraZeneca and its U.S. development partner Merck said their Lynparza drug cut the risk of the cancer progressing again by 41%. The figure was 38% for GSK's drug.

Inside the office of pharmaceutical company GlaxoSmithKline in Gurgaon, Haryana, India. 
Pradeep Gaur | Mint | Getty Images

The two companies said they would discuss the results with health-care regulators with a view to a wider label.

But different trial settings will make it difficult to predict how physicians will weigh up the two drugs.

While the Lynparza trial worked on the assumption that patients get an initial treatment of chemotherapy plus Roche's Avastin, the trial with GSK's Zejula included only patients who had initially gone through chemotherapy only.

AstraZeneca argues that more than half of advanced ovarian cancer patients in developed countries already get Avastin, with the rate increasing, while GSK says concerns about side effects may speak against the Roche drug.

Both companies, which are competing to burnish their oncology credentials, showed that not just the small group of women with mutated BRCA genes can benefit as the results also covered the full variety of ovarian cancer.

Many cancer cells have a limited ability to make DNA repairs during cell division, as healthy cells would. This feature makes tumors genetically volatile and helps them develop resistance to treatment over time.

Drugmakers try to use that to their advantage with PARP inhibitors, which block what is left of the DNA repair mechanism so cancer cells fail to replicate.

Mutated BRCA genes make the DNA repair particularly weak, which is why PARP inhibitors have been approved already for that subgroup.

Both trials showed benefit in using Zejula or Lynparza also in tumors with a wider range of genetic mutations that hamper DNA repairs.

Zejula was the lead compound of U.S. cancer specialist Tesaro, which GSK acquired for $5.1 billion in December.

Other approved PARP inhibitors, Pfizer's Talzenna and Clovis Oncology's Rubraca, are seen as further behind in terms of future revenue prospects. Abbvie is testing an experimental compound called veliparib.

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Retail

CVS suspends sales of Zantac brand and generic heartburn drug during safety review

Key Points
  • CVS Health said it will discontinue sales the popular Zantac heartburn treatment and its own generic ranitidine products after traces of a known carcinogen were found in some of the products by the FDA.
  • CVS said the move was taken out of caution while the FDA continues to review if low levels of NDMA in ranitidine — the active ingredient in Zantac — poses a health risk to patients.