Walgreens traded lower after the drugstore chain reported February sales fell 2.2 percent from the year ago period.
MGIC Investment and Radian Group both rallied up to 52-week highs after an upgrade from Barclays to "overweight" from "underweight."
Sears Holdings rallied sharply. According to a regulatory filing, Chairman & CEO Eddie Lampert purchased 1.2 million shares of the retailer for $44.36 per share in March.
Qihoo 360 Technology jumped to a new 52-week high ahead of the company's earnings after the bell.
Forty stocks on the S&P 500 hit record highs include Google, Walt Disney and Kellogg.
Home Depot also hit a new record high before turning lower.
And troubled retailer JCPenney hit a new 52-week low.
—By CNBC's Lori Spechler
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