Stocks closed down nearly 1 percent in a volatile session after the minutes from the last Fed policy setting meeting suggested the central bank is divided on when it may start to pull back on its monetary stimulus.
The market had moved higher earlier in the session when Federal Reserve Chairman Ben Bernanke reiterated that tapering bond purchases will depend on an improvement in the economic data.
The Dow Jones Industrial Average fell 80.41 points, or 0.52 percent, to close at 15307.17. Cisco led the blue chips lower, while Pfizer and Home Depot closed higher.
The last time the Dow was up over 150 points at the session highs, but closed down for the day was March 16, 2009.
The S&P 500 lost 13.81 points, or 0.8 percent, to finish at 1655.35. The Nasdaq dropped 38.82 points, or 1.11 percent, to close at 3463.30. Both the Dow and S&P were up as much as 1 percent earlier in the session.
All 10 S&P sectors fell, with utilities and materials pacing the declines.