Groysman's rebooted cabinet appears to strengthen the influence of Poroshenko in the government and on the economic side of policymaking in particular.
Oleksandr Danylyuk, 40, who is set to become finance minister, is the deputy head of Poroshenko's administration, while the economy minister and first deputy prime minister positions will be given to Stepan Kubiv, who is currently the president's representative in parliament.
They replace Yaresko, praised by Washington for her handling of Ukraine's debt crisis, and Aivaras Abromavicius, who as economy minister spearheaded a drive to privatise graft-ridden state firms, but quit in protest over corruption in February.
Poroshenko, whose confectionary business Roshen has made him Ukraine's sixth richest man, said the new government must honour reform commitments made under its $17.5 billion International Monetary Fund bailout.
"I stress the imperative and inviolable necessity of continuing cooperation with the IMF and other international lenders," he said.