In a lengthy Snapchat story posted on Thursday, Clinton's campaign attacked Trump's "Republican values" by comparing him to former Republican leaders like Abraham Lincoln, Ronald Reagan and George W. Bush, among others.
The campaign also used the face swap feature on the social media platform to superimpose faces of former presidents onto Trump's.
In what could be the first ever political attack ad on Snapchat, Clinton criticized Trump's rhetoric and well-publicized inflammatory comments about veterans, Muslims and a disabled reporter.
Representatives for Trump and Clinton's campaigns did not immediately respond to CNBC's request for comment.
Social media users took to Twitter to express amusement and concern over Clinton's millennial-inspired attack on Trump.