Over in South Korea, the Kospi slipped 0.25 percent to end at 2,515.43. Shares of Samsung Electronics finished the session 0.76 percent lower. Rival chipmaker SK Hynix edged down 0.4 percent after trading above the flat line earlier in the day.
In Australia, the S&P/ASX 200 lost 0.54 percent to close at 6,015.8 following the fall in base metals seen overnight. The materials sector led losses on the index, trading lower by 2.03 percent. Major mining names recorded significant declines: Rio Tinto fell 3.46 percent, BHP tumbled 2.91 percent and Fortescue Metals slid 3.01 percent by the end of the session.
Hong Kong's Hang Seng Index pulled back 0.13 percent by 3:00 p.m. HK/SIN after notching a record close on Tuesday. Financials were a mixed picture after rising in the last session: HSBC Holdings edged up 0.06 percent and China Construction Bank slipped 0.25 percent in the afternoon. Index heavyweight Tencent traded 0.81 percent higher and insurer AIA fell 0.95 percent.
Country Garden declined 5.85 percent by 3:00 p.m. HK/SIN after the property developer said in a Wednesday filing it intended to place 460 million shares and issue convertible bonds, which would raise some 23.5 billion Hong Kong dollars ($3 billion).
On the mainland, the Shanghai composite bucked the overall downward trend to eke out slight gains, closing 0.26 percent higher at 3,445.36. The Shenzhen composite, however, slid 0.3 percent to end at 1,921.74. The blue chip CSI 300 index closed off by 0.23 percent despite gains in the telecommunications and financials sectors, with Industrial and Commercial Bank of China rising 2.12 percent on the day.
Stateside, stock indexes closed in negative territory despite trading at record highs earlier in the session. The Dow Jones industrial average cracked the 26,000 barrier on Tuesday, but later reversed gains to finish the session lower by 0.04 percent, or 10.33 points, at 25,792.86.
Those declines came despite expectation-topping earnings reports as markets focused on the chances of a government shutdown stateside in the scenario Congress fails to pass a spending bill by Friday.