But plane crashes and fatal accident rates have declined, even as the number of flights and passengers have hit record highs, a trend industry analysts chalk up to higher safety standards, better maintenance, safer equipment and more training.
U.S. airlines have carried close to 7 billion people since the Colgan Air crash through this past January, on more than 80 million flights, according to the Department of Transportation. That was without a passenger death due to an accident or incident. (The figures do not include on-board passenger deaths due to health problems.)
Fatal crashes had been more common in previous decades, data from the National Transportation Safety Board show.
"Crashes were happening for every damn reason you could imagine," said Kevin Michaels, managing director of AeroDynamic Advisory, an aviation consulting firm. "There were crashes all the time."
But crashes have prompted changes in regulations and safety, although years often pass before the rules are introduced. More than four years after the crash Colgan Air Flight 3407, the Federal Aviation Administration announced an increase in the number flying hours required to fly for a commercial passenger or cargo airline as a first officer to 1,500 from 250 hours. A lack of pilot experience was cited in the crash.
In 1996, a fuel-tank explosion downed TWA Flight 800, a Boeing 747 bound for Paris from New York. All 230 people aboard were killed. Twelve years later, the FAA issued a requirement to install equipment that pumps nitrogen into fuel tanks to reduce oxygen and as a result, potential explosions.
The fatal engine failure aboard Southwest Flight 1380 on Tuesday, which came just days after a report on news program "60 Minutes" criticizing the safety record of budget carrier Allegiant Air, sparked some relatively quick action.
The engine's manufacturer, CFM International, a joint venture of General Electric and France's Safran Aircraft Engines, issued a service bulletin, calling for more stringent, ultrasonic checks of some CFM56-7B fan blades. The FAA made these checks mandatory for some engines shortly afterward in an "emergency" order, depending on how many times they've been used.
Southwest said its current maintenance program "meets or exceeds the requirements" set in the FAA's emergency order, issued Friday.
The National Transportation Safety Board is in the early stages of its investigation of the incident but is focusing on how a fan blade of the engine, a type that powers more than 6,000 aircraft worldwide, broke off.
Other challenges for airlines and regulators remain, even though the number of fatal accidents had declined in recent years. One issue is preventing injuries, or even death.
Airlines have struggled to inform passengers of safety procedures. A photo from Flight 1380 showed passengers wearing oxygen masks over their mouths, but not their noses as flight attendants instruct. Emergency evacuations on other flights showed passengers stopping to reach for luggage or filming videos.