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The stock, which was down all morning, extended its losses to close at $231.83. CA Technologies lost nearly 3 percent.
Paul called for a review of the proposed $19 billion merger during a Senate hearing on homeland security. He sent a formal review request to the U.S. Treasury later Wednesday, according to news site Axios.
It would be the second major challenge to a Broadcom merger this year. President Donald Trump blocked the chipmaker's proposed deal with Qualcomm in March, citing national security concerns from the U.S. Treasury's Committee on Foreign Investment in the United States.
"If [CFIUS] were looking at Broadcom previously, just because Broadcom has changed their domicile to [the U.S.] doesn't mean we shouldn't still look at Broadcom," Paul said, addressing Secretary of Homeland Security Kirstjen Nielsen.
Broadcom announced in July that it had agreed to acquire CA Technologies for $18.9 billion in cash. CA Technologies, which makes cloud-based and traditional enterprise software, would help diversify Broadcom, should the deal gain antitrust approvals in the U.S., the EU and Japan. The boards of both companies have already approved the deal.
"Broadcom and CA Technologies are both American companies, and there is no basis in fact or law for CFIUS review of our pending transaction," Broadcom said in a statement later Wednesday. "We have received HSR clearance and the approval of CA shareholders, and we have a clear path to completing the transaction in the fourth calendar quarter of 2018."
Broadcom's statement also made reference to an allegedly fraudulent memo related to the merger that the company claims has been circulating around Congress. A spokesperson for Paul's office said his comments were not related to any such memo.
— CNBC's Chloe Aiello and Tucker Higgins contributed to this report.