The mainland Chinese markets were mixed by the end of their trading day, with the Shanghai composite advancing around 0.42 percent to 2,953.82 and the Shenzhen component declining 0.916 percent to 9,005.77. The Shenzhen composite slipped 0.567 percent to 1,540.92.
Hong Kong's Hang Seng index also declined about 0.15 percent in its final hour of trading.
Meanwhile, shares in India were hit by another wave of uncertainty following renewed tensions between New Delhi and Islamabad. The Nifty 50 slipped around 0.59 percent while the Indian rupee shed about 0.5 percent against the greenback at 71.301.
Other major Asian stock markets, however, saw gains on the day.
Japan's Nikkei 225 rose 0.5 percent to close at 21,556.51 while the Topix advanced 0.2 percent to finish its trading day at 1,620.42. Shares of Fast Retailing, the company behind the Uniqlo chain of apparel stores, gained 2.67 percent.
South Korea's Kospi also added 0.37 percent to close at 2,234.79, as Hyundai Motor shares surged 5.31 percent after the company rejected on Tuesday a payout call by activist investor Elliot Management.
The ASX 200 in Australia rose 0.36 percent to close at 6,150.30, with majority of the sectors advancing.