Stocks in Asia were mixed on Wednesday amid growing uncertainty over the high-level trade negotiations between the U.S. and China due to commence later this week.
Mainland Chinese stocks recovered from an earlier slip to rise on the day, with the Shanghai composite up 0.39% to around 2,924.86 and Shenzhen component adding 0.34% to 9,506.56. The Shenzhen composite gained 0.654% to approximately 1,609.10.
Elsewhere, the Nikkei 225 in Japan slipped 0.61% on the day to 21,456.38 while the Topix index shed 0.3% to close at 1,581.70. In Australia, the S&P/ASX 200 finished its trading day 0.71% lower at 6,546.70.
Overall, the MSCI Asia ex-Japan index shed 0.58%.
Markets in South Korea were closed on Wednesday for a holiday.
Shares of Apple suppliers in Asia were mixed following criticism from Chinese state media on the U.S. tech giant's decision to allow an app on its app store used by protesters in Hong Kong. The app in question, HKmap.live, tracks the movement of police around the city.
Contract manufacturer Pegatron's stock fell 2%, as did shares of Taiwan Semiconductor Manufacturing Company, which was down 1.57%. iPhone assembler Hon Hai Precision Industry, better known as Foxconn, also dropped 1.49%.
Shares of China-based Luxshare slipped 0.95% while GoerTek recovered from an earlier tumble to rise 0.77% on the day. Both companies assemble Apple's AirPods.
The moves came as investors reacted to overnight developments in U.S.-China tensions. Washington expanded its trade blacklist to include some of China's top artificial intelligence firms on Monday, in response to Beijing's alleged treatment of predominantly Muslim ethnic minorities. For its part, China's Ministry of Commerce said the U.S. should "stop interfering" in the country's internal affairs and "remove" the relevant entities from the list "as soon as possible."
Those latest developments cloud the outlook for the upcoming U.S.-China trade negotiations, set to kick off on Thursday amid the looming prospect of more tariffs from Washington on goods from Beijing. The White House has scheduled an increase in U.S. tariffs on $250 billion worth of Chinese goods to 30% from 25% on Oct. 15. U.S. President Donald Trump has said the increase in duties will kick in if no progress is made in bilateral trade negotiations.
"It is clear from just the events of today and recent days that the trade negotiations with China are definitely not getting any closer to resolution. If anything, they're getting further away," Carl Tannenbaum, chief economist at Northern Trust, told CNBC's "Squawk Box" on Wednesday.
"The two sides — even though there are still negotiations scheduled for Thursday of this week in Washington — seem to be taking steps on both sides to distance themselves from one another," Tannenbaum added. "In that context, the trade headwind that the economy has been facing around the world is certainly going to remain there if not intensify."
The protracted trade fight between the U.S. and China has already lasted for more than a year, with both parties slapping tariffs on billions of dollars worth of each other's goods, denting investor sentiment and raising fears over the outlook for the global economy.
Overnight on Wall Street, stocks tumbled amid the dented hopes for a U.S.-China trade deal. The Dow Jones Industrial Average plunged 313.98 points to close at 26,164.04 while the S&P 500 slipped 1.6% to end its trading day stateside 2,893.06. The Nasdaq Composite dropped 1.7% to close at 7,823.78.
The U.S. dollar index, which tracks the greenback against a basket of its peers, was at 99.131 after touching highs around the 99.2 handle yesterday.
The Japanese yen traded at 107.13 against the dollar after strengthening from levels above 107.3 in the previous session. The Australian dollar changed hands at $0.6735 after seeing an earlier low of $0.6721.
Oil prices edged lower in the afternoon of Asian trading hours, with international benchmark Brent crude futures slipping 0.22% to $58.11 per barrel. U.S. crude futures declined 0.27% to $52.49 per barrel.
—CNBC's Fred Imbert contributed to this report.