Shares in the Asia-Pacific dropped sharply on Wednesday after indexes on Wall Street plunged following a higher-than-expected U.S. consumer price index report for August.
Japan's Nikkei 225 dropped 2.78% to 27,818.62, and the Topix index fell 1.97% to 1,947.46.
The Japanese yen earlier hovered around the 145-mark, its weakest levels since September 1998 – before strengthening after a report said the Bank of Japan conducted a "rate check."
The Hang Seng index in Hong Kong dipped 2.33% in the final hour of trade, and the Hang Seng Tech index fell 2.68%. In Australia, the S&P/ASX 200 shed 2.58% to 6,828.60.
The Kospi in South Korea lost 1.56% to 2,411.42 – the won passed the 1,390-mark against the greenback, the weakest levels since March 2009.
Mainland China's Shanghai Composite lost 0.8% to 3,237.54 and the Shenzhen Component fell 1.247% to 11,774.78.
MSCI's broadest index of Asia-Pacific shares outside Japan fell 2.26%.
The U.S. 2-year Treasury yield also reached 3.79%, the highest level since 2007. The Dow Jones Industrial Average lost 1,276.37 points, or 3.94%, to close at 31,104.97. The S&P 500 shed 4.32% to 3,932.69, and the Nasdaq Composite lost 5.16% to end the session at 11,633.57.
"What is perhaps most disconcerting in all this is that the strength in core inflation is very much service sector-led categories," said Ray Attrill, National Australia Bank's head of FX strategy, wrote in a note, adding the sector is primarily wage inflation-driven.
— CNBC's Jeff Cox, Jesse Pound and Carmen Reinicke contributed to this report.