The exchange-traded fund, with $6.9 billion assets under management, jumped more than 14%, its biggest daily pop since its inception in 2014.
More than 48 million shares of ARKK had changed hands, far surpassing its 30-day average volume of about 25 million.
Wood's disruptive darlings have been hit particularly hard this year as rising rates made growth names unappealing. These stocks could see a big rebound if easing price pressures lead the Federal Reserve to dial back its aggressive tightening efforts.
The innovation investor has been calling deflation for some time, betting the high prices were caused by the temporary Covid-related supply issue. Wood said recently that her conviction in deflation has increased, and Thursday's consumer price index report could signal that the trend has started to go in her direction.
She told investors in a webinar Tuesday that inflation will be influenced by companies slashing prices due to inventory excess heading into the holiday season.
ARKK, managed solely by Wood, is still down 61% this year. The innovation investor just doubled down on a slew of her favorite stocks this week, unfazed by the turmoil in many of these names.
Wood snapped up shares of six companies Wednesday, including her largest holdings of Zoom and Tesla. The investor also has been adding to her Coinbase stake for two straight days despite the potential collapse of popular crypto exchange FTX.
Tesla, ARKK's second-biggest holding, is still down more than 16% in November alone as Elon Musk rushed to sell billions of dollars worth of stock to help fund his acquisition of Twitter.