Asia-Pacific markets fell across the board as investors prepared for signals on U.S. monetary policy from central bankers' comments at the Jackson Hole meeting on Friday, including a speech by U.S. Federal Reserve chair Jerome Powell.
Japan's Nikkei 225 tumbled 2.05%, leading losses in Asia and closing at 31,624.28. The Topix was down 0.88%, ending at 2,266.4. Both indexes snapped four-day winning streaks.
Core inflation rate for Japan's capital Tokyo came in at 2.8% for August, slightly below the 2.9% expected by economists polled by Reuters. The core inflation rate strips out prices of fresh food.
Overall inflation for Tokyo was recorded at 2.9%, lower than the 3.2% seen in July.
In Australia, the S&P/ASX 200 also lost 0.93%, ending at 7,115.2. South Korea's Kospi fell 0.73%, finishing at 2,519.14 and the Kosdaq was lower by 0.26%, closing at 899.38.
Hong Kong's Hang Seng index was down 1.28% in its final hour, while mainland Chinese markets saw a smaller loss, with the CSI 300 slipping 0.38% and ending at 3,709.15.
On Thursday in the U.S., all three major indexes fell as the tech fueled rally ended, with the Dow Jones Industrial Average seeing its worst day since March, while the S&P 500 and the Nasdaq Composite saw their biggest one-day loss since Aug. 2.
The Dow closed 1.08% lower and the S&P 500 lost 1.35%. The Nasdaq saw the largest loss, shedding 1.87%.
— CNBC's Sarah Min and Alex Harring contributed to this report