Pizza Ranch said it has been working with investigators.
"Pizza Ranch independently ran over 40 tests on different products to test for the presence of E. Coli O157, and it was not found in any products tested," Ryan Achterhoff, chief administrative officer for Pizza Ranch, said in a statement. "We provided public health investigators with a list of all of our ingredients, as well as contact information for our ingredient suppliers. We also contacted the supplier of our dough mixes regarding this issue, with the request that they cooperate with state and federal health officials."
The restaurant has temporarily discontinued its use of its Skillet Dough and Original Dough mix due to reports that the products were a possible factor in the contraction of the illness.
"In addition, we instructed all Pizza Ranch locations to complete a special, precautionary cleaning of all surfaces and equipment used in dough preparation or service," Achterhoff said.
He said the likely source of the bacteria is an ingredient supplier and not the restaurant; the CDC confirmed that several people living multiple states away from a Pizza Ranch location have contracted the same strain of E. coli.
The states affected by this particular E. coli outbreak were Iowa, Illinois, Kansas, Nebraska, North Carolina, New Jersey, South Dakota, Wisconsin, and Minnesota.
Eight of the individuals who contracted the illness were hospitalized, including two children who developed hemolytic uremic syndrome (HUS), which can lead to kidney failure, a CDC spokeswoman said. No deaths have been reported.
Pritzker Olsen, a law firm in Kansas, told CNBC it is representing a girl who developed HUS, but has not yet filed a lawsuit.
Pizza Ranch has more than 180 locations in 13 states, all of which are open and serving the company's full menu.
CORRECTION: E. coli is a bacteria. That fact was misstated in an earlier version of this article.