The debate in Las Vegas comes at a critical moment for the Trump campaign: Clinton leads her Republican opponent by a healthy margin in the majority of national polls and appears poised to capture many of the decisive battleground states in the November election, according to most projections.
Chris Wallace of Fox News moderated.
Here's CNBC's latest debate coverage and analysis:
Trump on whether he will accept election results: 'I will look at it at the time'
Why these college Republicans think Trump is excelling in final debate
Clinton on Trump: Only one of us has shipped jobs to Mexico
Trump claims that Clinton Foundation is a 'criminal enterprise'
Social media lights up after Trump's 'such a nasty woman' comment
Trump blasts sexual misconduct claims: 'I don't know those people'
Op-Ed: Here we go again with Putin!
Clinton says Trump needs to admit, condemn Russian involvement in election hacks
Trump: 'We have some bad hombres and we're going to get them out'
Clinton: Trump's immigration plans would 'rip our country apart'
Trump: I'll appoint Supreme Court justices to overturn Roe v. Wade abortion case
Kyle Bass on 'circus clown' Trump, China's banking system and coming stagflation
Trump comes out hard for the Second Amendment, attacks Justice Ginsburg
Op-Ed: Trump blows it with response to Supreme Court questions
Hillary Clinton: Here's what I want in the Supreme Court
Even Ringling Bros is chiming in on the debate's social media circus
The two previous debates were bruising affairs that generated many more headlines from the candidates' attacks on each other than from any policy discussion.
Many pundits said the first debate went poorly for Trump, who elicited laughter when said he has a "much better temperament" than Clinton. The New York businessman later claimed he held back on making "inappropriate" comments about Bill Clinton. During that first faceoff, the Democratic nominee slammed Trump for perpetuating a false claim that President Barack Obama was not born in the United States.
The second debate came days after the release of a 2005 video featuring Trump bragging about groping women. Although some prominent Republicans called for Trump to drop out of the race because of the video, he apologized for his comments and counter-punched with personal attacks against Clinton on the debate stage.