Companies "need to operate in Asia in an increasingly competitive region. If you have to go across borders to get trade done, how are you going to do it in a region that has so many different regulations, so many different borders and so many different countries," she said of the concerns of AmCham members. AmCham is non-partisan.
"This is a real concern at the moment. Companies are actually just trying to get the job done and they do need U.S. government help to just deal with some of the regulatory issues," Joseph added.
The remaining 11 nations in the TPP have been working toward proceeding with a deal excluding the U.S.
Joseph's comments come as Wilbur Ross, the U.S. commerce secretary, tours Asia, stopping at China, Hong Kong, Thailand and Laos. Josephs called Ross' trip an encouraging signal of continued U.S. interest in the region.
There have been concerns the U.S. was becoming isolationist after Trump abandoned the TPP, a notion Ross dismissed as "fiction" propagated by the media in an interview with CNBC on Wednesday.