Asia-Pacific were mixed after the U.S. Federal Reserve hiked rates by 25 basis points as widely expected, bringing the federal funds rate range to 5%-5.25% — its highest level since August 2007.
The Fed in its post-meeting statement hinted at a possible pause in hikes ahead. It omitted a sentence present in the previous statement saying that "the Committee anticipates that some additional policy firming may be appropriate" for the Fed to achieve its 2% inflation goal.
China's factory activity fell into contraction for the first time in three months, with the Caixin China purchasing managers' index reading sliding to 49.5.
Stocks in mainland China were mixed after returning from the Labor Day holiday. The Shenzhen Component slid 0.57% to end the session at 11,273.86 and the Shanghai Composite climbed 0.82% to close at 3,350.45.
Hong Kong's Hang Seng index gained 1.29% in its final hour of trade and the Hang Seng Tech index rose 0.54%.
In Australia, the S&P/ASX 200 fell marginally to end at 7,193.1, as the country's trade surplus widened to AU$15.27 billion in March.
South Korea's Kospi closed marginally down at 2,500.94, while the Kosdaq rose 0.22% to 845.06. Japanese markets are closed for a holiday Thursday.
Overnight in the U.S., all three major indexes slid after the Fed decision, extending their losing streak to three days.
The Dow Jones Industrial Average slid 0.80%, and the S&P 500 dipped 0.70%.The Nasdaq Composite saw the smallest loss, shedding 0.46%.
— CNBC's Hakyung Kim and Sarah Min contributed to this report