U.S. stock index futures pointed to a slightly lower open on Wednesday, as investors readied to delve through another cluster of earnings from the U.S. corporate sphere.
Dow Jones industrial average futures fell 26 points, while S&P 500 and Nasdaq 100 futures both slipped 3.75 points.
Earnings season continues to be in full swing half way through the trading week, with IAC, 21st Century Fox, Monster Beverage, Square, Hostess Brands, Roku, Sunrun and Twilio expected to publish earnings after the bell.
Earlier on Wednesday, Regeneron and Humana reported better-than-expected earnings.
Politics is also expected to set a slight tone on Wall Street as U.S. President Donald Trump continues his journey abroad in Asia.
On Wednesday, Trump continued to draw attention to the threat that North Korea poses to the rest of the world, as he traveled from South Korea to China. In an address to South Korean lawmakers, Trump said that Kim Jong-Un's regime "has interpreted America's past restraint as weakness."
"This would be a fatal miscalculation. This is a very different administration than the United States has had in the past," said Trump, warning North Korea to "not underestimate us".
On the data front, weekly mortgage applications volume remained unchanged from the previous week.
Oil prices were relatively mixed, as news that crude imports in China fell to their lowest in a year, weighed on investor sentiment.
Overseas, European stocks were trading under pressure during morning trade, while markets in Asia pointed in different directions by the close. In the previous session, the broader U.S. market saw a mixed session.
—CNBC's Nyshka Chandran contributed to this report