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Meet the 2018 CNBC Disruptor 50 companies

In the sixth annual Disruptor 50 list, CNBC features private companies — from biotech and machine learning to transportation and retail and even exploring outer space — whose innovations are changing the world. These forward-thinking start-ups have not only identified unexploited niches in the market that have the potential to become billion-dollar businesses, a majority of them already are billion-dollar businesses. A startling 33 disruptors this year are unicorns that have already reached or passed the billion-dollar mark.

Unseating corporate giants is no easy feat. But we ranked those venture capital–backed companies doing the best job. In aggregate, these 50 companies have raised nearly $78 billion in venture capital at an implied Disruptor 50 list market valuation of more than $350 billion, according to PitchBook data. Many already are part of our daily lives, whether or not we know it. Read more about the trends that stand out in the 2018 list ranking — from drones and genes to the battles for control in the rapidly growing ridesharing, lodging and cryptocurrency industries — and the methodology used to select this year's Disruptor companies.

1SpaceXTaking the lead in the new space race.
2UberFaring better in the post-Travis era.
3AirbnbRewriting the book on bookings.
4Didi ChuxingHow do you say "Uber" in Mandarin?
5LyftSticking to the high road.
6GrabJust another rideshare unicorn ...
723andMeA genetics house call.
8UdacityNanodegree your way to a new job.
9Rent the RunwayA closet in the cloud.
10CoinbaseBuy
11TransferWiseEating up foreign-exchange fees.
12Oscar Health200
13PayoneerHelping companies get paid around the world.
14SurveyMonkeyA way to better answers.
15ProgynyFertile ground for disruption.
16AdyenThe company that gave PayPal the wooden shoe.
17TheRealRealWhat's in your closet?
18Indigo AgricultureSeeding the world.
19EzetapPowering India's cashless revolution.
20PelotonA new spin on spinning.
21Ginkgo BioworksMicrobe economics.
22LISNRNo Wi-Fi? No problem.
23WeWorkFor when you need some space.
24EllevestWall Street for
25Zipline InternationalDrones to the rescue.
26LanzaTechWon't let carbon go to waste.
27CrowdstrikeInto the breach
28XiaomiA $100 billion iPhone competitor
29FlirteyThe robot revolution takes flight.
30Veritas GeneticsYour whole genome
31HouzzImproving home improvement.
32C3 IoTWhat are those devices saying?
33Palantir TechnologiesThey know you
34DarktraceA digital immune boost.
35DuolingoHow do you say ...
36Pinterest100 billion ideas shared.
37ThinxAn underwear innovator takes on Tampax.
38RobinhoodTurning trading upside down.
39UptakeBig machines break
40DrawbridgeAn ad's journey from screen to screen.
41InMobiA personalized mobile ad experience.
42CourseraWe don't need no formal IT education.
43StripeCracking the code on getting your internet business paid.
44IllumioWe all have vulnerabilities.
45FanaticsThey root for everyone
46Auris HealthA surgical robot pioneer scrubs in
47LuminarHow self-driving cars see around corners.
48Apeel SciencesThe end of rotten food.
49GitHubThe ultimate source for open source.
50SoFiYes